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Article

Complex relation of <i>HLA-DRB1*1501</i> , age at menarche, and age at multiple sclerosis onset

27 Jul 2016

Abstract excerpt

OBJECTIVE: To examine the relationship between 2 markers of early multiple sclerosis (MS) onset, 1 genetic (HLA-DRB1*1501) and 1 experiential (early menarche), in 2 cohorts. METHODS: We included 540 white women with MS or clinically isolated syndrome (N = 156 with genetic data available) and 1,390 white women without MS but with a first-degree relative with MS (Genes and Environment in Multiple Sclerosis [GEMS])....

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PMID: 27504495
DOI: 10.1212/nxg.0000000000000088

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