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Genetic and environmental mediators of multiple sclerosis susceptibility but not early severity run in families.

Multiple sclerosis and related disorders - 1 May 2026

Corsten Cato E A, Marques Ana M, van Hasselt Yifan, van Rooij Jeroen, Smets Ide, van Luijn Marvin M, Neuteboom Rinze F, Wokke Beatrijs, Smolders Joost

Abstract excerpt

BACKGROUND: Multiple sclerosis (MS) susceptibility and severity are mediated by different genetic and environmental risk factors. Familial aggregation in MS is partially explained by susceptibility determinants, yet impact on early disease course after clinically isolated syndrome (CIS) is uncertain. We investigated associations of reported familial MS with genetic and environmental risk factors, and with...

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PMID: 41795504
DOI: 10.1016/j.msard.2026.107101

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