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Article

A higher burden of multiple sclerosis genetic risk confers an earlier onset.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jul 2022

Misicka Elina, Davis Mary F, Kim Woori, Brugger Steven W, Beales Jeremy, Loomis Stephanie, Bronson Paola G, Briggs Farren Bs

Abstract excerpt

BACKGROUND: Age at onset of multiple sclerosis (MS) is an objective, influential predictor of the evolution of MS independent of disease duration. OBJECTIVES: Determine the influence of MS genetic predisposition on age of onset. METHODS: We conducted a comprehensive investigation of MS risk variants and age at onset in 3495 non-Latinx white individuals, including for combinations of HLA-DRB1*15:01 alleles and...

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PMID: 34709090
DOI: 10.1177/13524585211053155

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