Article
Factors influencing pharmacokinetics of warfarin in African-Americans: implications for pharmacogenetic dosing algorithms.
Pharmacogenomics - 1 Jan 2015
Nagai Rui, Ohara Minami, Cavallari Larisa H, Drozda Katarzyna, Patel Shitalben R, Nutescu Edith A, Perera Minoli A, Hernandez Wenndy, Kaneko Naoko, Hibiya Manabu, Takahashi Harumi
Abstract excerpt
AIM: This study attempted to identify predictors of S-warfarin clearance (CL[S]) and to make a pharmacokinetic evaluation of genotype-based dosing algorithms in African-Americans. METHODS: Using plasma S-warfarin concentration (Cp[S]) at a steady state and eight SNPs previously shown to influence warfarin dose in African-Americans, CL(S) and its predictors were estimated by population pharmacokinetic analysis in...
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