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Article

A warfarin-dosing model in Asians that uses single-nucleotide polymorphisms in vitamin K epoxide reductase complex and cytochrome P450 2C9.

Clinical pharmacology and therapeutics - 1 Oct 2006

Tham Lai-San, Goh Boon-Cher, Nafziger Anne, Guo Jia-Yi, Wang Ling-Zhi, Soong Richie, Lee Soo-Chin

Abstract excerpt

INTRODUCTION: Because of the unique lack of genetic diversity despite the multiethnicity in the Asian population, we hypothesize that single-nucleotide polymorphisms in cytochrome P450 (CYP) 2C9 (CYP2C9*3) and vitamin K epoxide reductase complex subunit 1 (VKORC1) at position 381, used to infer VKORC1haplotype in combination with demographic factors, can accurately predict warfarin doses. The aims of this study...

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Source

Identifiers

PMID: 17015052
DOI: 10.1016/j.clpt.2006.06.009

Genes

VKORC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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