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Article

Genotype-driven pharmacokinetic simulations of warfarin levels in Puerto Ricans.

Drug metabolism and personalized therapy - 18 Aug 2020

Reyes-González Stephanie, de Las Barreras Camila, Reynaldo Gledys, Rodríguez-Vera Leyanis, Vlaar Cornelis, Mejias Vilmali Lopez, Monbaliu Jean-Christophe M, Stelzer Torsten, Mangas Victor, Duconge Jorge

Abstract excerpt

OBJECTIVES: The inter-individual variability of warfarin dosing has been linked to genetic polymorphisms. This study was aimed at performing genotype-driven pharmacokinetic (PK) simulations to predict warfarin levels in Puerto Ricans. METHODS: Analysis of each individual dataset was performed by one-compartmental modeling using WinNonlin®v6.4. The ke of warfarin given a cytochrome P450 2C9 (CYP2C9) genotype...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34704696
DOI: 10.1515/dmpt-2020-0135
PMCID: PMC7892629

Genes

CYP2C9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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