Article

Human genetics implicates a BACH2-NRF2 axis in fetal hemoglobin activation

2023-03-24

Abstract excerpt

Human genetic studies have identified key regulators of fetal hemoglobin (HbF) expression, including BCL11A, resulting in therapeutic advances. Yet the mechanisms by which HbF expression is activated remain incompletely understood. Here, we conduct a multi-ancestry genome-wide association study of HbF levels in 28,237 individuals that identifies 131 conditionally-independent associations across 12 genomic regions....

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Literature Corpus work: 73b0b43a-9977-5f52-8f27-0d0eaad26627
DOI: 10.1101/2023.03.24.23287659

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