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Article

β-Catenin C-terminal signals suppress p53 and are essential for artery formation.

Nature communications - 8 Aug 2016

Riascos-Bernal Dario F, Chinnasamy Prameladevi, Cao Longyue Lily, Dunaway Charlene M, Valenta Tomas, Basler Konrad, Sibinga Nicholas E S

Abstract excerpt

Increased activity of the tumour suppressor p53 is incompatible with embryogenesis, but how p53 is controlled is not fully understood. Differential requirements for p53 inhibitors Mdm2 and Mdm4 during development suggest that these control mechanisms are context-dependent. Artery formation requires investment of nascent endothelial tubes by smooth muscle cells (SMCs). Here, we find that embryos lacking SMC...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to beta Catenin

Share to Cell Survival

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Identifiers

PMID: 27499244
DOI: 10.1038/ncomms12389
PMCID: PMC4979065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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