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Article

CYR61 (CCN1) is essential for placental development and vascular integrity.

Molecular and cellular biology - 1 Dec 2002

Mo Fan-E, Muntean Andrew G, Chen Chih-Chiun, Stolz Donna B, Watkins Simon C, Lau Lester F

Abstract excerpt

CYR61 (CCN1) is a member of the CCN family of secreted matricellular proteins that includes connective tissue growth factor (CCN2), NOV (CCN3), WISP-1 (CCN4), WISP-2 (CCN5), and WISP-3 (CCN6). First identified as the product of a growth factor-inducible immediate-early gene, CYR61 is an extracellular matrix-associated angiogenic inducer that functions as a ligand of integrin receptors to promote cell adhesion,...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Nick-End Labeling

Share to Neovascularization, Physiologic

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Share to Platelet Endothelial Cell Adhesion Molecule-1

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Source

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Identifiers

PMID: 12446788
DOI: 10.1128/MCB.22.24.8709-8720.2002
PMCID: PMC139880

Genes

CCN1
CCN2
CCN3
CCN4
CCN5
CCN6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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CYR61 (CCN1) is essential for placental development and vascular integrity.PMID 12446788Read ↗

The Matricellular Protein Cysteine-rich Protein 61 (CCN1/Cyr61) Enhances Physiological Adaptation of Retinal Vessels and Reduces Pathological Neovascularization Associated with Ischemic RetinopathySemantic proximity Read ↗

The human Cyr61 gene is a transcriptional target of transforming growth factor beta in cancer cells.Semantic proximity Read ↗

The matricellular protein CCN1 is essential for cardiac development.Semantic proximity Read ↗

Decreased expression of the angiogenic regulators CYR61 (CCN1) and NOV (CCN3) in human placenta is associatedwith pre-eclampsiaSemantic proximity Read ↗

Eyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilarities.Semantic proximity Read ↗

The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis.Semantic proximity Read ↗

Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossificationSemantic proximity Read ↗

The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veinsSemantic proximity Read ↗

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