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Article

Vascular smooth muscle cell Smad4 gene is important for mouse vascular development.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2012

Mao Xia, Debenedittis Paige, Sun Yong, Chen Jianfeng, Yuan Kaiyu, Jiao Kai, Chen Yabing

Abstract excerpt

OBJECTIVE: Smad4 is a central mediator of transforming growth factor-β/bone morphogenetic protein signaling that controls numerous developmental processes as well as homeostasis in the adult. The present studies sought to understand the function of Smad4 expressed in vascular smooth muscle cells (VSMC) in vascular development and the underlying mechanisms. METHODS AND RESULTS: Breeding of Smad4(flox/flox) mice...

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Source

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Identifiers

PMID: 22772757
DOI: 10.1161/ATVBAHA.112.253872
PMCID: PMC3442374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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