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The MDM2-p53 axis regulates norrin/frizzled4 signaling and blood-CNS barrier function

8 Jul 2025

Abstract excerpt

Norrin-induced activation of β-catenin–dependent signaling through the receptor frizzled4 in endothelial cells (ECs) is essential for establishing and maintaining blood-CNS barrier function. We sought to determine how this pathway is modulated under stress or disease conditions. Specifically, we investigated the role of p53 in endothelial blood-CNS barriers because increased abundance of the transcription factor...

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PMID: 40627684
DOI: 10.1126/scisignal.adt0983

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