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Article

Regulation of pre-natal circle of Willis assembly by vascular smooth muscle Notch signaling.

Developmental biology - 1 Sept 2013

Yang Ke, Banerjee Suhanti, Proweller Aaron

Abstract excerpt

The circle of Willis (cW) is a major arterial collateral structure interconnecting hemispheric circulation within the brain, and in humans, anatomical variation of the cW is linked to stroke risk. Our prior studies on adult mice deficient in vascular smooth muscle cell (vSMC) Notch signaling revealed altered cerebroarterial maturation and patterning, including an anatomically incompetent cW similar to human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23769842
DOI: 10.1016/j.ydbio.2013.06.007
PMCID: PMC3805056

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