Article
Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2013
Leeper Nicholas J, Raiesdana Azad, Kojima Yoko, Kundu Ramendra K, Cheng Henry, Maegdefessel Lars, Toh Ryuji, Ahn G-One, Ali Ziad A, Anderson D Ryan, Miller Clint L, Roberts Scott C, Spin Joshua M, de Almeida Patricia E, Wu Joseph C, Xu Baohui, Cheng Karen, Quertermous Maximilian, Kundu Soumajit, Kortekaas Kim E, Berzin Erica, Downing Kelly P, Dalman Ronald L, Tsao Philip S, Schadt Eric E, Owens Gary K, Quertermous Thomas
Abstract excerpt
OBJECTIVE: Genomewide association studies have implicated allelic variation at 9p21.3 in multiple forms of vascular disease, including atherosclerotic coronary heart disease and abdominal aortic aneurysm. As for other genes at 9p21.3, human expression quantitative trait locus studies have associated expression of the tumor suppressor gene CDKN2B with the risk haplotype, but its potential role in vascular...
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