Article
The POR rs1057868-rs2868177 GC-GT diplotype is associated with high tacrolimus concentrations in early post-renal transplant recipients.
Acta pharmacologica Sinica - 1 Sept 2016
Liu Shu, Chen Rong-Xin, Li Jun, Zhang Yu, Wang Xue-Ding, Fu Qian, Chen Ling-Yan, Liu Xiao-Man, Huang Hong-Bing, Huang Min, Wang Chang-Xi, Li Jia-Li
Abstract excerpt
AIM: Cytochrome P450 oxidoreductase (POR) is the only flavoprotein that donates electrons to all microsomal P450 enzymes (CYP), and several POR SNPs have been shown to be important contributors to altered CYP activity or CYP-mediated drug metabolism. In this study we examined the association between 6 POR SNPs and tacrolimus concentrations in Chinese renal transplant recipients. METHODS: A total of 154 renal...
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