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Article

Multigene predictors of tacrolimus exposure in kidney transplant recipients.

Pharmacogenomics - 1 Jul 2015

Pulk Rebecca A, Schladt David S, Oetting William S, Guan Weihua, Israni Ajay K, Matas Arthur J, Remmel Rory P, Jacobson Pamala A

Abstract excerpt

AIM: Determine the effect of the genetic variants beyond CYP3A5*3 on tacrolimus disposition. PATIENTS & METHODS: We studied genetic correlates of tacrolimus trough concentrations with POR*28, CYP3A4*22 and ABCC2 haplotypes in a large, ethnically diverse kidney transplant cohort (n = 2008). RESULTS: Subjects carrying one or more CYP3A5*1 alleles had lower tacrolimus trough concentrations (p = 9.2 × 10(-75)). The...

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Share to Cytochrome P-450 CYP3A
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Immunosuppressive Agents

Share to Kidney Transplantation

Share to Multidrug Resistance-Associated Protein 2

Share to Tacrolimus

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Source

Open in PubMed Open full text

Identifiers

PMID: 26067485
DOI: 10.2217/pgs.15.42
PMCID: PMC4527535

Genes

CYP3A5
CYP3A4
POR
ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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