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Article

Impact of the CYP3A5, CYP3A4, COMT, IL-10 and POR genetic polymorphisms on tacrolimus metabolism in Chinese renal transplant recipients.

PloS one - 1 Jan 2014

Li Chuan-Jiang, Li Liang, Lin Li, Jiang Hai-Xia, Zhong Ze-Yan, Li Wei-Mo, Zhang Yan-Jun, Zheng Ping, Tan Xu-Hui, Zhou Lin

Abstract excerpt

Tacrolimus is a widely used immunosuppressive drug for preventing the rejection of solid organ transplants. The efficacy of tacrolimus shows considerable variability, which might be related to genetic variation among recipients. We conducted a retrospective study of 240 Chinese renal transplant recipients receiving tacrolimus as immunosuppressive drug. The retrospective data of all patients were collected for 40...

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Source

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Identifiers

PMID: 24465960
DOI: 10.1371/journal.pone.0086206
PMCID: PMC3897654

Genes

COMT
POR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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