Article
P450 oxidoreductase *28 (POR*28) and tacrolimus disposition in pediatric kidney transplant recipients--a pilot study.
Therapeutic drug monitoring - 1 Apr 2014
Gijsen Violette M G J, van Schaik Ron H N, Soldin Offie P, Soldin Steven J, Nulman Irena, Koren Gideon, de Wildt Saskia N
Abstract excerpt
BACKGROUND: Both age and CYP3A5 genotype are important determinants of tacrolimus disposition in pediatric kidney transplant recipients. In a recent study in adults, POR*28 was associated with increased dosing requirements early after transplant of CYP3A5-expressing kidney transplant recipients. The authors aimed to evaluate the additional contribution of POR*28 to early tacrolimus disposition in pediatric kidney...
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