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Article

Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.

PeerJ - 1 Jan 2024

Zhang Tao, Chen Xiaorong, Liu Yuan, Zhang Lei

Abstract excerpt

Purpose: Glutathione S-transferase mu (GSTM) belongs to the group of phase II drug-metabolizing enzymes, and the GSTM1 genetic variant has been reported to have a potential association with the metabolism of immunosuppressive drug after renal transplantation. The effect of donor and recipient GSTMs genetic variants on tacrolimus (Tac) metabolism was the focus of our investigation in this study. Methods: A total...

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Share to Cytochrome P-450 CYP3A
Share to Genotype
Share to Glutathione Transferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunosuppressive Agents

Share to Liver Transplantation

Share to Polymorphism, Single Nucleotide

Share to Tacrolimus

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Source

Open in PubMed Open full text

Identifiers

PMID: 39465171
DOI: 10.7717/peerj.18360
PMCID: PMC11512548

Genes

GSTM3
CYP3A5
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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