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Article

Next-generation sequencing survey of biliary tract cancer reveals the association between tumor somatic variants and chemotherapy resistance.

Cancer - 1 Dec 2016

Ahn Daniel H, Javle Milind, Ahn Chul W, Jain Apurva, Mikhail Sameh, Noonan Anne M, Ciombor Kristen, Wu Christina, Shroff Rachna T, Chen James L, Bekaii-Saab Tanios

Abstract excerpt

BACKGROUND: Biliary tract cancers (BTCs) are uncommon and are associated with a dismal prognosis. Combinations of gemcitabine and platinum chemotherapy (gemcitabine and platinum-based therapy [GP]) form the standard approach for treating advanced BTC. To characterize the spectrum of mutations and to identify potential biomarkers for a GP response in BTC, this study evaluated the genomic landscape and assessed...

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Source

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Identifiers

PMID: 27495988
DOI: 10.1002/cncr.30247
PMCID: PMC5222890

Genes

BTC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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