Article
Understanding homologous recombination repair deficiency in biliary tract cancers: clinical implications and correlation with platinum sensitivity.
ESMO open - 1 Aug 2024
Mavroeidi I-A, Burghofer J, Kalbourtzis S, Taghizadeh H, Webersinke G, Piringer G, Kasper S, Schreil G, Liffers S T, Reichinger A, Kirchweger P, Heibl S, Hamacher R, Schmitt C A, Schuler M, Prager G W, Kersting D, Treckmann J, Schildhaus H-U, Rumpold H, Siveke J T, Doleschal B
Abstract excerpt
BACKGROUND: Biliary tract cancers (BTCs) exhibit high mortality rates and significant heterogeneity in both clinical and molecular characteristics. This study aims to molecularly characterize a cohort of patients with BTC, with a specific focus on genomic alterations within homologous recombination repair (HRR) genes in a real-world setting. PATIENTS AND METHODS: We carried out a retrospective analysis on 256...
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