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Article

The Molecular Landscape of Pancreatobiliary Cancers for Novel Targeted Therapies From Real-World Genomic Profiling.

Journal of the National Cancer Institute - 9 Sept 2022

Umemoto Kumiko, Yamamoto Hiroyuki, Oikawa Ritsuko, Takeda Hiroyuki, Doi Ayako, Horie Yoshiki, Arai Hiroyuki, Ogura Takashi, Mizukami Takuro, Izawa Naoki, Moore Jay A, Sokol Ethan S, Sunakawa Yu

Abstract excerpt

BACKGROUND: Chemotherapies have limited efficacy in pancreatic cancer (PC) and biliary tract cancer (BTC), underscoring the need for new regimens. Recently, tumor-agnostic approaches have been developed for some targeted therapies in advanced solid tumors; however, the frequency of alterations by clinical and genomic background is unclear in PC and BTC. METHODS: To assess the frequencies of druggable gene...

Topics

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Biomarkers, Tumor
Child
Gastrointestinal Neoplasms
Genomics
Pancreatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 35583261
DOI: 10.1093/jnci/djac106
PMCID: PMC9468278

Genes

BTC
PC
ERBB2
FGFR2
BRAF
CDK12
KRAS
BRCA2
EGFR
GATA6
PIK3CA

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