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Article

Single nucleotide polymorphisms in an intergenic chromosome 2q region associated with tissue factor pathway inhibitor plasma levels and venous thromboembolism.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2016

Dennis J, Truong V, Aïssi D, Medina-Rivera A, Blankenberg S, Germain M, Lemire M, Antounians L, Civelek M, Schnabel R, Wells P, Wilson M D, Morange P-E, Trégouët D-A, Gagnon F

Abstract excerpt

Essentials Tissue factor pathway inhibitor (TFPI) regulates the blood coagulation cascade. We replicated previously reported linkage of TFPI plasma levels to the chromosome 2q region. The putative causal locus, rs62187992, was associated with TFPI plasma levels and thrombosis. rs62187992 was marginally associated with TFPI expression in human aortic endothelial cells. Click to hear Ann Gil's presentation on new...

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Identifiers

PMID: 27490645
DOI: 10.1111/jth.13431
PMCID: PMC6544906

Genes

TFPI

Variants

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