Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease.

doi:10.1038/s41588-019-0519-3

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Article

Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease.

Nature genetics - 1 Nov 2019

Klarin Derek, Busenkell Emma, Judy Renae, Lynch Julie, Levin Michael, Haessler Jeffery, Aragam Krishna, Chaffin Mark, Haas Mary, Lindström Sara, Assimes Themistocles L, Huang Jie, Min Lee Kyung, Shao Qing, Huffman Jennifer E, Kabrhel Christopher, Huang Yunfeng, Sun Yan V, Vujkovic Marijana, Saleheen Danish, Miller Donald R, Reaven Peter, DuVall Scott, Boden William E, Pyarajan Saiju, Reiner Alex P, Trégouët David-Alexandre, Henke Peter, Kooperberg Charles, Gaziano J Michael, Concato John, Rader Daniel J, Cho Kelly, Chang Kyong-Mi, Wilson Peter W F, Smith Nicholas L, O'Donnell Christopher J, Tsao Philip S, Kathiresan Sekar, Obi Andrea, Damrauer Scott M, Natarajan Pradeep

Abstract excerpt

Venous thromboembolism is a significant cause of mortality1, yet its genetic determinants are incompletely defined. We performed a discovery genome-wide association study in the Million Veteran Program and UK Biobank, with testing of approximately 13 million DNA sequence variants for association with venous thromboembolism (26,066 cases and 624,053 controls) and meta-analyzed both studies, followed by independent...

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PMID: 31676865
DOI: 10.1038/s41588-019-0519-3
PMCID: PMC6858581

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