Prognostic impact of the adverse molecular-genetic profile on long-term outcomes following allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia.

doi:10.1038/s41409-021-01255-4

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Prognostic impact of the adverse molecular-genetic profile on long-term outcomes following allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia.

Bone marrow transplantation - 1 Aug 2021

Daher-Reyes Georgina, Kim TaeHyung, Novitzky-Basso Igor, Kim Kyuoung Ha, Smith Adam, Stockley Tracy, Capochichi Jose-Mario, Al-Shaibani Zeyad, Pasic Ivan, Law Arjun, Lam Wilson, Michelis Fotios V, Gerbitz Armin, Viswabandya Auro, Lipton Jeffrey, Kumar Rajat, Mattsson Jonas, Schimmer Aaron, McNamara Caroline, Murphy Tracy, Maze Dawn, Gupta Vikas, Sibai Hassan, Chan Steven, Yee Karen, Minden Mark, Zhang Zhaolei, Schuh Andre, Kim Dennis D H

Abstract excerpt

The impact of adverse risk genetic profiles on outcomes in acute myeloid leukemia (AML) patients following allogeneic hematopoietic stem cell transplantation (HCT) has not been fully elucidated. Accordingly, we have profiled somatic mutations at diagnosis using next-generation sequencing (NGS) in 178 AML patients who received allogeneic HCT. NGS revealed 598 somatic mutations in 165/178 patients (92.7%)....

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PMID: 33767401
DOI: 10.1038/s41409-021-01255-4

Genes

TP53
DNMT3A
FLT3
IDH2
NPM1
RUNX1
TET2

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