Article
The spectrum of association in HLA region with rheumatoid arthritis in a diverse Asian population: evidence from the MyEIRA case-control study.
Arthritis research & therapy - 30 Jan 2021
Tan Lay Kim, Too Chun Lai, Diaz-Gallo Lina Marcela, Wahinuddin Sulaiman, Lau Ing Soo, Heselynn Hussein, Nor-Shuhaila Shahril, Gun Suk Chyn, Eashwary Mageswaran, Mohd-Shahrir Mohamed Said, Ainon Mohd Mokhtar, Azmillah Rosman, Muhaini Othman, Shahnaz Murad, Alfredsson Lars, Klareskog Lars, Padyukov Leonid
Abstract excerpt
BACKGROUND: Fine-mapping of human leukocyte antigen (HLA) region for rheumatoid arthritis (RA) risk factors has identified several HLA alleles and its corresponding amino acid residues as independent signals (i.e., HLA-A, HLA-B, HLA-DPB1, and HLA-DQA1 genes), in addition to the well-established genetic factor in HLA-DRB1 gene. However, this was mainly performed in the Caucasian and East Asian populations, and...
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