Engagement of SLAMF3 enhances CD4 ⁺ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus

Abstract excerpt

Signaling lymphocytic activation molecule family 3 (SLAMF3/Ly9) is a coregulatory molecule implicated in T-cell activation and differentiation. Systemic lupus erythematosus (SLE) is characterized by aberrant T-cell activation and compromised IL-2 production, leading to abnormal regulatory T-cell (Treg) development/function. Here we show that SLAMF3 functions as a costimulator on CD4(+) T cells and influences IL-2...

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