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Article

CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORγt recruitment to the IL17A promoter in human T lymphocytes.

The Journal of biological chemistry - 2 Nov 2012

Chatterjee Madhumouli, Hedrich Christian M, Rauen Thomas, Ioannidis Christina, Terhorst Cox, Tsokos George C

Abstract excerpt

Th17 lymphocytes play a key role during immune responses against bacteria and fungi and are involved in the pathophysiology of multiple autoimmune disorders. The co-stimulatory molecules SLAMF3 and SLAMF6 have been implicated in the formation of Th17 phenotypes and IL-17A expression. Increased surface expression of SLAMF3 and SLAMF6 has been linked with disease activity in systemic lupus erythematosus. Here we...

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Source

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Identifiers

PMID: 22989874
DOI: 10.1074/jbc.M112.415067
PMCID: PMC3488086

Genes

SLAMF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORγt recruitment to the IL17A promoter in human T lymphocytes.PMID 22989874Read ↗

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