Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORγt recruitment to the IL17A promoter in human T lymphocytes.

The Journal of biological chemistry - 2 Nov 2012

Chatterjee Madhumouli, Hedrich Christian M, Rauen Thomas, Ioannidis Christina, Terhorst Cox, Tsokos George C

Abstract excerpt

Th17 lymphocytes play a key role during immune responses against bacteria and fungi and are involved in the pathophysiology of multiple autoimmune disorders. The co-stimulatory molecules SLAMF3 and SLAMF6 have been implicated in the formation of Th17 phenotypes and IL-17A expression. Increased su...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to CD28 Antigens
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Interleukin-17

Share to Lupus Erythematosus, Systemic

Share to NFATC Transcription Factors

Share to Nuclear Receptor Subfamily 1, Group F, Member 3

Source

Open in PubMed Open full text

Identifiers

PMID: 22989874
DOI: 10.1074/jbc.M112.415067
PMCID: PMC3488086

Genes

SLAMF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22989874-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORγt recruitment to the IL17A promoter in human T lymphocytes.PMID 22989874Read ↗

Engagement of SLAMF3 enhances CD4 <sup>+</sup> T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosusSemantic proximity Read ↗

SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions.Semantic proximity Read ↗

The SLAM family receptors: Potential therapeutic targets for inflammatory and autoimmune diseasesSemantic proximity Read ↗

SLAMF7 engagement super-activates macrophages in acute and chronic inflammationSemantic proximity Read ↗

Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3Semantic proximity Read ↗

RORγt and RORα signature genes in human Th17 cellsSemantic proximity Read ↗

Soluble IL-7Rα/sCD127 in Health, Disease, and Its Potential Role as a Therapeutic AgentSemantic proximity Read ↗

NFAT primes the human RORC locus for RORγt expression in CD4+ T cellsSemantic proximity Read ↗

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper CellsSemantic proximity Read ↗

The Role of the CD28 Family Receptors in T-Cell ImmunomodulationSemantic proximity Read ↗

Human Fc Receptor-like 3 Inhibits Regulatory T Cell Function and Binds Secretory IgA.Semantic proximity Read ↗

Co-stimulatory modulation in rheumatoid arthritis: the role of (CTLA4-Ig) abatacept.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.