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Article

SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions.

Seminars in immunopathology - 1 Jun 2010

Detre Cynthia, Keszei Marton, Romero Xavier, Tsokos George C, Terhorst Cox

Abstract excerpt

One or more of the signaling lymphocytic activation molecule (SLAM) family (SLAMF) of cell surface receptors, which consists of nine transmembrane proteins, i.e., SLAMF1-9, are expressed on most hematopoietic cells. While most SLAMF receptors serve as self-ligands, SLAMF2 and SLAMF4 use each other as counter structures. Six of the receptors carry one or more copies of a unique intracellular tyrosine-based switch...

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Share to Antigens, CD
Share to Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lupus Erythematosus, Systemic

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Share to Receptors, Cell Surface

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Source

Open in PubMed Open full text

Identifiers

PMID: 20146065
DOI: 10.1007/s00281-009-0193-0
PMCID: PMC2868096

Genes

SLAMF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions.PMID 20146065Read ↗

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The Emerging and Diverse Roles of Src‐Like Adaptor Proteins in Health and DiseaseSemantic proximity Read ↗

The SLAM family receptors: Potential therapeutic targets for inflammatory and autoimmune diseasesSemantic proximity Read ↗

Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.Semantic proximity Read ↗

CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell DevelopmentSemantic proximity Read ↗

Pillars Article: The X-Linked Lymphoproliferative Disease Gene Product SAP Regulates Signals Induced through the Co-Receptor SLAM. Nature. 1998. 395: 462-469.Semantic proximity Read ↗

Detailed Phenotypic and Functional Characterization of a Rare, Antibody-Dependent SLAM-Associated Protein Expression Pattern.Semantic proximity Read ↗

Expression patterns of signaling lymphocytic activation molecule family members in peripheral blood mononuclear cell subsets in patients with systemic lupus erythematosusSemantic proximity Read ↗

Engagement of SLAMF3 enhances CD4 <sup>+</sup> T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosusSemantic proximity Read ↗

Ly9 (CD229)-Deficient Mice Exhibit T Cell Defects yet Do Not Share Several Phenotypic Characteristics Associated with SLAM- and SAP-Deficient MiceSemantic proximity Read ↗

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