Inflammatory factor-mediated miR-155/SOCS1 signaling axis leads to Treg impairment in systemic lupus erythematosus

Abstract excerpt

Inflammatory factors in systemic lupus erythematosus (SLE) trigger a signaling cascade in regulatory T cells (Tregs), leading to their functional impairment. This process involves the upregulation of miR-155 and downregulation of SOCS1, with a concomitant decrease in Foxp3 expression and an increased NF-κB activity. These changes compromise Treg stability and function, contributing to SLE progression. Notably,...

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