Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SLAM family receptors and SAP adaptors in immunity.

Annual review of immunology - 1 Jan 2011

Cannons Jennifer L, Tangye Stuart G, Schwartzberg Pamela L

Abstract excerpt

The signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first identified as the protein affected in most cases of X-linked lymphoproliferative (XLP) syndrome, a rare genetic disorder characterized by abnormal responses to Epstein-Barr virus infection, lymphoproliferative syndromes, and dysgammaglobulinemia. SAP consists almost entirely of a single SH2 protein domain that interacts with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Autoimmune and Inflammatory Disorders Research
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunodeficiency and Autoimmune Disorders

Share to Intracellular Signaling Peptides and Proteins

Share to Lupus Erythematosus, Systemic

Share to Lymphoproliferative Disorders

Share to Mutation

Source

Identifiers

PMID: 21219180
DOI: 10.1146/annurev-immunol-030409-101302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SLAM family receptors and SAP adaptors in immunity.PMID 21219180Read ↗

Regulation of Cellular and Humoral Immune Responses by the SLAM and SAP Families of MoleculesSemantic proximity Read ↗

The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease.Semantic proximity Read ↗

SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions.Semantic proximity Read ↗

The Emerging and Diverse Roles of Src‐Like Adaptor Proteins in Health and DiseaseSemantic proximity Read ↗

Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.Semantic proximity Read ↗

Pathogenesis and diagnosis of X-linked lymphoproliferative disease.Semantic proximity Read ↗

Pillars Article: The X-Linked Lymphoproliferative Disease Gene Product SAP Regulates Signals Induced through the Co-Receptor SLAM. Nature. 1998. 395: 462-469.Semantic proximity Read ↗

The SLAM family receptors: Potential therapeutic targets for inflammatory and autoimmune diseasesSemantic proximity Read ↗

XLP: clinical features and molecular etiology due to mutations in SH2D1A encoding SAP.Semantic proximity Read ↗

Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.Semantic proximity Read ↗

Detailed Phenotypic and Functional Characterization of a Rare, Antibody-Dependent SLAM-Associated Protein Expression Pattern.Semantic proximity Read ↗

Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAPSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.