Article
Unexpected frequency of genomic alterations in histologically normal colonic tissue from colon cancer patients.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Oct 2016
Conconi Donatella, Redaelli Serena, Bovo Giorgio, Leone Biagio Eugenio, Filippi Emanuela, Ambrosiani Luciana, Cerrito Maria Grazia, Grassilli Emanuela, Giovannoni Roberto, Dalprà Leda, Lavitrano Marialuisa
Abstract excerpt
As shown by genomic studies, colorectal cancer (CRC) is a highly heterogeneous disease, where copy number alterations (CNAs) may greatly vary among different patients. To explore whether CNAs may be present also in histologically normal tissues from patients affected by CRC, we performed CGH + SNP Microarray on 15 paired tumoral and normal samples. Here, we report for the first time the occurrence of CNAs as a...
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