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Cytoprotective autophagy maintains leukemia-initiating cells in murine myeloid leukemia

2 Aug 2016

Abstract excerpt

Despite advances in the treatment of acute myeloid leukemia (AML), relapse and drug resistance frequently occur. Therefore, detailed mechanisms of refractoriness, including leukemia-initiating cell (LIC) biology, should be elucidated to treat AML. The self-degradative property of cytosolic macromolecules is central to autophagy and can contribute to homeostasis and stress response. Recent reports suggest the...

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PMID: 27480114
DOI: 10.1182/blood-2015-12-684696

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