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Autophagy in Chronic Myeloid Leukaemia: Stem Cell Survival and Implication in Therapy

31 Aug 2013

Abstract excerpt

The insensitivity of Chronic Myeloid Leukaemia (CML) stem cells to Tyrosine Kinase Inhibitor (TKI) treatment is now believed to be the main reason for disease persistence experienced in patients. It has been shown that autophagy, an evolutionarily conserved catabolic process that involves degradation of unnecessary or harmful cellular components via lysosomes, is induced following TKI treatment in CML cells. Of...

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PMID: 23941517
DOI: 10.2174/15680096113139990088

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