Ferritinophagy is a Druggable Vulnerability of Quiescent Leukemic Stem Cells

Abstract excerpt

Acute myeloid leukemia (AML) remains a challenging hematological malignancy with poor prognosis and limited treatment options. Leukemic stem cells (LSCs) contributes to therapeutic failure, post-therapy relapse and adverse outcome. Here, we investigated the role of quiescence and its associated molecular mechanisms in AML pathogenesis and LSCs functions, and identified potential vulnerabilities for therapeutic int...

Topics

Open a Topic to create a Post that cites this publication.

• Acute Myeloid Leukemia Research
• Autophagy in Disease and Therapy
• Bone Marrow
• Disease Management
• Disease Susceptibility
• Genetic Heterogeneity
• Molecular Targeted Therapy
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

1924e6d5-4083-5d51-b419-384459de20bd

DOI

10.1101/2023.12.18.572101