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Article

Targeting autophagy to fight hematopoietic malignancies

1 Sept 2010

Abstract excerpt

Macroautophagy, referred hereafter to as autophagy is an evolutionary conserved catabolic process for the degradation and recycling of macromolecules, bulk cytoplasm and dammaged organelles. Autophagy is activated under stress conditions induced by nutrient deprivation, hypoxia and drug treatments. Morphologically, autophagic cells are characterized by the accumulation of double membrane cytoplasmic vesicules...

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PMID: 20703092
DOI: 10.4161/cc.9.17.13048

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