Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NRF1-enhanced miR-4458 alleviates cardiac hypertrophy through releasing TTP-inhibited TFAM.

In vitro cellular & developmental biology. Animal - 1 Feb 2020

Yang Mengsi, Zhang Jing, Jin Xiaoqin, Li Chao, Zhou Gaoliang, Feng Jun

Abstract excerpt

Growing evidence suggests the crucial role of microRNAs (miRNAs) in regulating basic cell functions, and therefore participating in the pathologic development of diverse human diseases, including cardiac hypertrophy. Herein, we explained that miR-4458 was distinctly stimulated in Ang II-stimulated hypertrophic H9c2 cells. Intriguingly, miR-4458 inhibition led to exacerbated hypertrophic phenotypes in Ang...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin II
Share to Cardiomegaly
Share to Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MicroRNAs

Share to Protein Stability

Share to Transcription Factors

Share to Transcription, Genetic

Source

Identifiers

PMID: 31942725
DOI: 10.1007/s11626-019-00419-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NRF1-enhanced miR-4458 alleviates cardiac hypertrophy through releasing TTP-inhibited TFAM.PMID 31942725Read ↗

Quantitative Proteomics Analysis Revealed the Potential Role of lncRNA Ftx in CardiomyocytesSemantic proximity Read ↗

MicroRNA-129-5p targets keap-1 to protect against cardiomyocyte hypertrophy via Nrf2 pathwaySemantic proximity Read ↗

TLR2 activates AP-1 to facilitate CTGF transcription and stimulate doxorubicin-induced myocardial injurySemantic proximity Read ↗

Circular RNA circFTO promotes pressure overload-induced cardiac hypertrophy via encoding a novel protein FTO-36aaSemantic proximity Read ↗

The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constrictionSemantic proximity Read ↗

Expression Profile of microRNAs in Hypertrophic Cardiomyopathy and Effects of microRNA-20 in Inducing Cardiomyocyte Hypertrophy Through Regulating Gene MFN2Semantic proximity Read ↗

NRF-1 promotes FUNDC1-mediated mitophagy as a protective mechanism against hypoxia-induced injury in cardiomyocytesSemantic proximity Read ↗

Sex-specific regulation of cardiac microRNAs targeting mitochondrial proteins in pressure overloadSemantic proximity Read ↗

MiR‐26a‐5p alleviates cardiac hypertrophy and dysfunction via targeting ADAM17Semantic proximity Read ↗

Unlocking the therapeutic potential of lncRNA FENDRR in DCM: novel targets and insights via the miR-296-5p/HMGA1 axisSemantic proximity Read ↗

The mechanism of myocardial hypertrophy regulated by the interaction between mhrt and myocardinSemantic proximity Read ↗

LncRNA promoted inflammatory response in ischemic heart failure through regulation of miR-455-3p/TRAF6 axisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.