Article
The A-nucleotide preference of HIV-1 in the context of its structured RNA genome.
RNA biology - 1 Feb 2013
van Hemert Formijn J, van der Kuyl Antoinette C, Berkhout Ben
Abstract excerpt
A bipartition of HIV-1 RNA genome sequences into single- and double-stranded nucleotides is possible based on the secondary structure model of a complete 9 kb genome. Subsequent analysis revealed that the well-known lentiviral property of A-accumulation is profoundly present in single-stranded domains, yet absent in double-stranded domains. Mutational rate analysis by means of an unrestricted model of nucleotide...
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