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Article

[Mutation Frequencies in HIV-1 Genome in Regions Containing Efficient RNAi Targets As Calculated from Ultra-Deep Sequencing Data].

Molekuliarnaia biologiia - 1 Jan 2000

Kretova O V, Gorbacheva M A, Fedoseeva D M, Kravatsky Y V, Chechetkin V R, Tchurikov N A

Abstract excerpt

HIV-1 is one of the most variable viruses. The development of gene therapy technology using RNAi for AIDS/HIV-1 treatment is a potential alternative for traditional anti-retroviral therapy. Anti-HIV-1 siRNA should aim to exploit the most conserved viral targets. Using the deep sequencing of potential RNAi targets in 100-nt HIV-1 genome fragments from the clinical HIV-1 subtype A isolates in Russia, we found that...

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Share to Acquired Immunodeficiency Syndrome
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29989577
DOI: 10.7868/S0026898418030084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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