Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Mutation frequencies in HIV-1 subtype-A genome in regions containing efficient RNAi targets].

Molekuliarnaia biologiia - 1 Jan 2000

Kravatsky Y V, Chechetkin V R, Fedoseeva D M, Gorbacheva M A, Kretova O V, Tchurikov N A

Abstract excerpt

The development of gene-therapy technology using RNAi for AIDS/HIV-1 treatment is a prospective alternative to traditional anti-retroviral therapy. RNAi targets could be selected in HIV-1 transcripts and in CCR5 mRNA. Previously, we experimentally selected a number of efficient siRNAs that target HIV-1 RNAs. The viral genome mutates frequently, and RNAi strength is very sensitive, even for a single mismatches....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pairing
Share to Codon
Share to Genome, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Targeted Therapy

Share to Mutation Rate

Share to RNA Interference

Share to RNA, Small Interfering

Share to Russia

Source

Identifiers

PMID: 27414786
DOI: 10.7868/S0026898416020117

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Mutation frequencies in HIV-1 subtype-A genome in regions containing efficient RNAi targets].PMID 27414786Read ↗

[Mutation Frequencies in HIV-1 Genome in Regions Containing Efficient RNAi Targets As Calculated from Ultra-Deep Sequencing Data].Semantic proximity Read ↗

[Mutation Frequencies in RNAi Targets in HIV-1 Genomes Obtained from Blood Plasma of Patients Receiving Anti-Retroviral Therapy].Semantic proximity Read ↗

Analysis of Variability in HIV-1 Subtype A Strains in Russia Suggests a Combination of Deep Sequencing and Multitarget RNA Interference for Silencing of the Virus.Semantic proximity Read ↗

A Bioinformatic Pipeline for Monitoring of the Mutational Stability of Viral Drug Targets with Deep-Sequencing Technology.Semantic proximity Read ↗

HIV-1 tolerates changes in A-count in a small segment of the pol gene.Semantic proximity Read ↗

Unselected mutations in the human immunodeficiency virus type 1 genome are mostly nonsynonymous and often deleterious.Semantic proximity Read ↗

An RNAi in silico approach to find an optimal shRNA cocktail against HIV-1.Semantic proximity Read ↗

[Characterization of the structure of the 5'-LTR region of HIV-1 subtype A wide spread in Russia].Semantic proximity Read ↗

RNAi-mediated inhibition of HIV-1 by targeting partially complementary viral sequences.Semantic proximity Read ↗

An HIV type 1 subtype A strain of low genetic diversity continues to spread among injecting drug users in Russia: study of the new local outbreaks in Moscow and Irkutsk.Semantic proximity Read ↗

[Analysis of the prevalence of CCR5 coreceptor antagonist resistance mutations among HIV-1 variants in Russia].Semantic proximity Read ↗

[HIV-1 resistance in the Yamal region and the comparison of mutation frequency with various score values].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.