Article
RNA Viruses and RNAi: Quasispecies Implications for Viral Escape.
Viruses - 19 Jun 2015
Presloid John B, Novella Isabel S
Abstract excerpt
Due to high mutation rates, populations of RNA viruses exist as a collection of closely related mutants known as a quasispecies. A consequence of error-prone replication is the potential for rapid adaptation of RNA viruses when a selective pressure is applied, including host immune systems and antiviral drugs. RNA interference (RNAi) acts to inhibit protein synthesis by targeting specific mRNAs for degradation...
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