Article
A Bioinformatic Pipeline for Monitoring of the Mutational Stability of Viral Drug Targets with Deep-Sequencing Technology.
Viruses - 23 Nov 2017
Kravatsky Yuri, Chechetkin Vladimir, Fedoseeva Daria, Gorbacheva Maria, Kravatskaya Galina, Kretova Olga, Tchurikov Nickolai
Abstract excerpt
The efficient development of antiviral drugs, including efficient antiviral small interfering RNAs (siRNAs), requires continuous monitoring of the strict correspondence between a drug and the related highly variable viral DNA/RNA target(s). Deep sequencing is able to provide an assessment of both the general target conservation and the frequency of particular mutations in the different target sites. The aim of...
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