Article
Rare Germline Copy Number Variations and Disease Susceptibility in Familial Melanoma.
The Journal of investigative dermatology - 1 Dec 2016
Shi Jianxin, Zhou Weiyin, Zhu Bin, Hyland Paula L, Bennett Hunter, Xiao Yanzi, Zhang Xijun, Burke Laura S, Song Lei, Hsu Chih Hao, Yan Chunhua, Chen Qingrong, Meerzaman Daoud, Dagnall Casey L, Burdette Laurie, Hicks Belynda, Freedman Neal D, Chanock Stephen J, Yeager Meredith, Tucker Margaret A, Goldstein Alisa M, Yang Xiaohong R
Abstract excerpt
Mounting evidence suggests that copy number variations (CNVs) can contribute to cancer susceptibility. The main goal of this study was to evaluate the role of germline CNVs in melanoma predisposition in high-risk melanoma families. We used genome-wide tiling comparative genomic hybridization and single nucleotide polymorphism arrays to characterize CNVs in 335 individuals (240 melanoma cases) from American...
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