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Article

Integrated case-control and somatic-germline interaction analyses of melanoma susceptibility genes.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jun 2018

Yu Yao, Hu Hao, Chen Jiun-Sheng, Hu Fulan, Fowler Jerry, Scheet Paul, Zhao Hua, Huff Chad D

Abstract excerpt

While a number of genes have been implicated in melanoma susceptibility, the role of protein-coding variation in melanoma development and progression remains underexplored. To better characterize the role of germline coding variation in melanoma, we conducted a whole-exome case-control and somatic-germline interaction study involving 322 skin cutaneous melanoma cases from The Cancer Genome Atlas and 3607 controls...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29317335
DOI: 10.1016/j.bbadis.2018.01.007
PMCID: PMC6501568

Genes

MITF
MTAP
BRCA2
FANCA

Provenance

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