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Article

Germline copy number variations and cancer predisposition.

Future oncology (London, England) - 1 Apr 2012

Krepischi Ana Cristina Victorino, Pearson Peter Lees, Rosenberg Carla

Abstract excerpt

We present an overview of the role of germline copy number variations (CNVs) in cancer predisposition. CNVs represent a significant source of genetic diversity, although the mechanisms by which they influence cancer susceptibility still remain largely unknown. Approximately 100 highly penetrant germline mutant genes are now known to cause cancer predisposition inherited in a Mendelian fashion; in this review, we...

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PMID: 22515447
DOI: 10.2217/fon.12.34

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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