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Article

Germline copy number variation and cancer risk.

Current opinion in genetics & development - 1 Jun 2010

Kuiper Roland P, Ligtenberg Marjolijn J L, Hoogerbrugge Nicoline, Geurts van Kessel Ad

Abstract excerpt

The human genome is subject to substantial structural variation, including copy number variation (CNV). Constitutional CNVs may either represent benign polymorphic variants or be associated with disease, including cancer predisposition. Rare nonpolymorphic CNVs, that is DNA lesions that result in gene deletions, inversions, and/or fusions, may be responsible for a high cancer risk. In addition, we previously...

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Identifiers

PMID: 20381334
DOI: 10.1016/j.gde.2010.03.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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