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Article

Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization study.

Genes, chromosomes & cancer - 1 Aug 2010

Gast Andreas, Scherer Dominique, Chen Bowang, Bloethner Sandra, Melchert Stephanie, Sucker Antje, Hemminki Kari, Schadendorf Dirk, Kumar Rajiv

Abstract excerpt

We performed DNA microarray-based comparative genomic hybridization to identify somatic alterations specific to melanoma genome in 60 human cell lines from metastasized melanoma and from 44 corresponding peripheral blood mononuclear cells. Our data showed gross but nonrandom somatic changes speci...

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Source

Identifiers

PMID: 20544847
DOI: 10.1002/gcc.20785

Genes

BRAF
NRAS
PTEN
CCND1
CDK4
CCNE1
EGFR
MDM2
MITF
NOTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20544847-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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