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Article

Copy number changes of clinically actionable genes in melanoma, non-small cell lung cancer and colorectal cancer-A survey across 822 routine diagnostic cases.

Genes, chromosomes & cancer - 1 Nov 2016

Pfarr Nicole, Penzel Roland, Klauschen Frederick, Heim Daniel, Brandt Regine, Kazdal Daniel, Jesinghaus Moritz, Herpel Esther, Schirmacher Peter, Warth Arne, Weichert Wilko, Endris Volker, Stenzinger Albrecht

Abstract excerpt

Targeted deep massive parallel sequencing has been implemented in routine molecular diagnostics for high-throughput genetic profiling of formalin-fixed paraffin-embedded (FFPE) cancer samples. This approach is widely used to interrogate simple somatic mutations but experience with the analysis of copy number variations (CNV) is limited. Here, we retrospectively analyzed CNV in 822 cancer cases (135 melanoma, 468...

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Source

Identifiers

PMID: 27218826
DOI: 10.1002/gcc.22378

Genes

BRAF
EGFR
KIT
KRAS
MYC
NRAS
ABL1
FGFR3
GNA11
IGF2
JAK3
KDR
MDM2
MET
NOTCH1
PDGFRA
RET
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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