Article
The genetic landscape of paediatric de novo acute myeloid leukaemia as defined by single nucleotide polymorphism array and exon sequencing of 100 candidate genes.
British journal of haematology - 1 Jul 2016
Olsson Linda, Zettermark Sofia, Biloglav Andrea, Castor Anders, Behrendtz Mikael, Forestier Erik, Paulsson Kajsa, Johansson Bertil
Abstract excerpt
Cytogenetic analyses of a consecutive series of 67 paediatric (median age 8 years; range 0-17) de novo acute myeloid leukaemia (AML) patients revealed aberrations in 55 (82%) cases. The most common subgroups were KMT2A rearrangement (29%), normal karyotype (15%), RUNX1-RUNX1T1 (10%), deletions of 5q, 7q and/or 17p (9%), myeloid leukaemia associated with Down syndrome (7%), PML-RARA (7%) and CBFB-MYH11 (5%)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.