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Article

Identification of MGMT promoter methylation sites correlating with gene expression and IDH1 mutation in gliomas.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Oct 2016

Zhang Jie, Yang Jian-Hui, Quan Jia, Kang Xing, Wang Hui-Juan, Dai Peng-Gao

Abstract excerpt

O6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation was reported to be an independent prognostic and predictive factor in glioma patients who received temozolomide treatment. However, the predictive value of MGMT methylation was recently questioned by several large clinical studies. The purpose of this study is to identify MGMT gene promoter CpG sites or region whose methylation were closely...

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Share to Brain Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27468718
DOI: 10.1007/s13277-016-5153-4

Genes

MGMT
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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