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Article

Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation.

Neuro-oncology - 19 Feb 2018

Kessler Tobias, Sahm Felix, Sadik Ahmed, Stichel Damian, Hertenstein Anne, Reifenberger Guido, Zacher Angela, Sabel Michael, Tabatabai Ghazaleh, Steinbach Joachim, Sure Ulrich, Krex Dietmar, Grosu Anca-L, Bewerunge-Hudler Melanie, Jones David, Pfister Stefan M, Weller Michael, Opitz Christiane, Bendszus Martin, von Deimling Andreas, Platten Michael, Wick Wolfgang

Abstract excerpt

Background: O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is a predictive biomarker in glioblastoma. We investigated whether this marker furthermore defines a molecularly distinct tumor subtype with clinically different outcome. Methods: We analyzed copy number variation (CNV) and methylation profiles of 1095 primary and 92 progressive isocitrate dehydrogenase wildtype glioblastomas,...

Topics

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Brain Neoplasms
DNA Copy Number Variations
DNA Modification Methylases
DNA Repair Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isocitrate Dehydrogenase

Tumor Suppressor Proteins

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Open in PubMed Open full text

Identifiers

PMID: 29016808
DOI: 10.1093/neuonc/nox160
PMCID: PMC5817966

Genes

MGMT
PDGFRA
EGFR
GBX2
GLI2
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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